PLATELETS AND THROMBOPOIESIS Critical role of Src-Syk-PLC 2 signaling in megakaryocyte migration and thrombopoiesis
نویسندگان
چکیده
1Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham; and 2Rheumatology Research Group, Institute of Biomedical Research, Division of Immunity & Infection, Medical Research Council (MRC) Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
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PLATELETS AND THROMBOPOIESIS A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets
T-cell ubiquitin ligand-2 (TULA-2) is a recently discovered histidine tyrosine phosphatase thought to be ubiquitously expressed. In this work, we have investigated whether TULA-2 has a key role in platelet glycoprotein VI (GPVI) signaling. This study indicates that TULA-2 is expressed in human and murine platelets and is able to associate with Syk and dephosphorylate it. Ablation of TULA-2 resu...
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